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ACE Fluid Mono (Angiotensine–Converting–Enzyme)

The ACE Fluid Mono Angiotensine–Converting–Enzyme test is a halide activated membrane bound Exopeptidase that has a central role in the control of blood pressure. ACE catalyses the conversion of Angiotensin I to the powerful vasoconstrictor Angiotensin II and also inactivates circulating Bradykinin. ACE is present in the vascular beds of most organs, however, the
highest levels are found in the endothelial cells of pulmonary capillaries. ACE is considered to be the principal source of the serum enzyme.
The presence (I) or absence (D) of a 287 base pair fragment on the gene for ACE gives rise to three ACE genotypes, II, DD and ID. Since the discovery of the I/D polymorphism, further studies have shown that serum ACE activity is influenced by genotype. DD individuals have nearly twice the ACE activity of II individuals, with values from ID individuals being intermediate.
The measurement of serum ACE is widely used to aid in the differential diagnosis of clinically active pulmonary Sarcoidosis and for monitoring the effectiveness of steroid therapy. ACE measurement is also becoming widely used for monitoring the effects of ACE inhibitors in the treatment of hypertension and heart failure.

PRINCIPLE
The mti-diagnostics ACE reagent is based on the method first described by Holmquist et al.

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