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Copper Fluid Colour Test

Copper Fluid Colour Test
Divalent copper (Cu++) forms complexes with proteins. The major functions of copper metalloproteins involve oxidation-reduction; most known copper containing enzymes bind and react directly with molecular oxygen. In plasma approximately 95% of copper is bound to the alpha-2-globulin ceruloplasmin, an oxidase with ferroxidase activity. There is evidence that marginal copper deficiency is associated with heart disease, bone and joint osteoarthritis and osteoporosis. Also decreased antioxidant protection is result of a decreased level of copper.

Intended use
Divalent copper (Cu++) forms complexes with proteins. The major function of copper metalloproteins involve oxidation-reduction; most known copper containing enzymes bind and react directly with molecular oxygen. In plasma approximately 95% of copper is bound to the alpha-2-globulin ceruloplasmin, an oxidase with ferroxidase activity. There is evidence that marginal copper deficiency is associated with heart disease, bone and joint osteoarthritis and osteoporosis. Also decreased antioxidant protection I result of a decreased level of copper.

Test principle
In a pH 4.7 buffer system, copper is released from its carrier protein, the ceruloplasmin, and forms with the specific complexant 3,5-DiBr-PAESA [4-(3,5-dibromo-2-pyridylazo)-N-ethyl-N-(3-sulfopropyl)aniline] a stable coloured complex. The colour intensity of this complex is proportional to the amount of copper in the sample.

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