LDL-Cholesterol Heparin (Precipitation reagent) Mo

LDL-Cholesterol Heparin (Precipitation reagent) Mono
LDL is responsible for the reverse transport of cholesterol from the peripheral cells to the liver. Here, cholesterol is transformed to bile acids which are excreted into the intestine via the biliary tract. Monitoring of LDL- cholesterol in serum is of clinical importance since an inverse correlation exists between serum LDL- cholesterol concentrations and the risk of atherosclerotic disease. Elevated LDL- cholesterol concentrations are protective against coronary heart disease, while reduced HDL- cholesterol concentrations, particularly in conjunction with elevated triglycerides, increase the cardiovascular risk.

A variety of methods are available to determine LDL-cholesterol, including ultracentrifugation, electrophoresis, HPLC, and precipitation-bases methods. Of these precipitation-based methods are used routinely. LDL cholesterol is first separated by precipitating apoprotein B-containing lipoproteins from serum by using a combination of a polyanion and a divalent cation, such as dextran sulfate/magnesium chloride or phosphotungstate/magnesium chloride.

Intended use
Enzymatic in vitro assay for the direct quantitative determination of LDL-cholesterol in human serum and plasma

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