Magnesium Xylidylblue Mono Fluid

Magnesium Xylidylblue Mono Fluid
Magnesium along with potassium is a major intracellular cation. Mg2+ is a cofactor of many enzyme systems. Thus, alI ATP-dependent enzymatic reactions require Mg2+ as a cofactor in the ATP-magnesium complex. Approximately 69% of magnesium ions are stored in bone. The rest are part of the intermediary metabolism about 70% being present in free form while the other 30% is bound to proteins (especially albumin), citrates, phosphate, and other complex formers. The Mg2+ serum level is kept constant within very narrow limits (0.65-1.05 mmol/I). Regulation takes place mainly via the kidneys, especially via the ascending loop of Henle.

This assay is used for diagnosing and monitoring hypomagnesemia (magnesium deficiency) and hypermagnesemia (magnesium excess). Numerous studies have shown a correlation between magnesium deficiency and changes in calcium-, potassium- and phosphate homeostasis which are associated with cardiac disorders such as ventricular arrhythmias that cannot be treated by conventional therapy, increased sensitivity to digoxin coronary artery spasms, and sudden death. Additional concurrent symptoms include neuromuscular and neuropsychiatric disorders. Hypermagnesemia is found in acute and chronic renal failure, magnesium excess, and magnesium release from the intracellular space.

in addition to atomic absorption spectrometry (AAS), complexometric methods can also be used to determine magnesium.
The method described here is based on the reaction of magnesium with xylidyl blue in alkaline solution containing EGTA to mask the calcium in the sample

Intended use
In vitro test for the quantitative determination of magnesium in human serum, plasma and urine.

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