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Microprotein Pyrogallolphthalein Fluid

Microprotein Pyrogallolphthalein Fluid
Urine is formed by ultrafiltration of plasma across the glomerular capillary wall. Proteins with a relative molecule mass > 40 000 are almost completely retained, while smaller substances easily enter the glomerular filtrate.
Most CSF protein originates by diffusion from plasma across the blood-CSF barrier. Elevated levels occur as a result of increased permeability of the blood-CFS barrier or with increased local synthesis of immunoglobulins.

Turbidimetric methods using trichloroacetic acid (TCA) or sulfosalicylic acid (SSA) require precipitation of the protein in the sample; the resulting turbidity may be unstable and flocculate. Dye-binding methods such as

Protein measurements in urine are used in the diagnosis and treatment of disease conditions such as renal or heart diseases, or thyroid disorders, which are characterized by proteinuria or albuminuria.

CSF protein measurements are used in the diagnosis and treatment of conditions such as meningitis, brain tumors, and infections of the central nervous systems.

Intended use
For the quantitative determination or protein in urine and cerebrospinal fluid on automated clinical chemistry analyzers.

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